Paid Diploma / Master's Thesis
Modeling and process control for a continuous biopharmaceutical production line
Ref. No. DA189
To dedicated students of electrical engineering, mechanical engineering, biomedical engineering, chemical and process engineering, digital engineering, physics, or related disciplines.
OBJECTIVE
The focus of this thesis is on improving the sustainability of a biopharmaceutical manufacturing line. This should be achieved by applying feedback control concepts and manipulating the process parameters of the selected unit operations, e.g., of a perfusion bioreactor, or multiple filtration and chromatography units.
Process models enabling simulation based development and model-based control algortihms are required. Computationally efficient dynamic models, focusing on the parameters relevant for the developed control concepts will be developed and evaluated for this purpose.
POSSIBLE TOPICS ARE
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Development and implementation of a process model for a biopharmaceutical unit operation (e.g., chromatography)
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Development of suitable model-based control algorithms for specified units
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Simulation-based evaluation and improvement of model-based control algorithms
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Development of plant-wide control algorithms improving the overall sustainability metrics
WITHIN THE FRAMEWORK OF THIS DIPLOMA / MASTER’S THESIS WE OFFER THE FOLLOWING
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Extensive participation in a top-level and industrially relevant research project in an international environment
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Working with class-leading equipment (Phylon OSeeT)
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Supervised training in the task
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Assistance of experienced staff with the implementation of innovative ideas
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Access to highly modern infrastructure on campus of Graz University of Technology
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Assistance with the publication of results
FINANCING
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Compensation on the basis of a service contract
If you are interested in writing your thesis at the interface between university research and industry/ business and to contribute to the optimization of product and process development in the pharmaceutical industry, please apply directly via our website.
